Bioinspired Synthesis of (−)‐PF‐1018

Bioinspired Synthesis of Magnetic Nanoparticles

Bioinspired iterative synthesis of polyketides

Diverse array of biopolymers and second metabolites (particularly polyketide natural products) has been manufactured in nature through an enzymatic iterative assembly of simple building blocks. Inspired by this strategy, molecules with inherent modularity can be efficiently synthesized by repeated succession of similar reaction sequences. This privileged strategy has been widely adopted in synt...

Bioinspired Synthesis of Silver Nanoparticles

Disease-causing microbes that have become resistant to drug therapy are an increasing public health problem. Therefore there is an urgent need to develop new bactericides. Silver nanoparticles are the metal of choice as they hold the promise to kill microbes effectively. Silver nanoparticles take advantages of the oligodynamic effect that silver has on microbes. In this work we have synthesized...

Bioinspired total synthesis of (±)-yezo'otogirin C.

The first and protective group-free total synthesis of (±)-yezo'otogirin C has been achieved from 3-methyl-4-prenylcyclohex-2-enone in eight steps with 23% overall yield. The tricyclic core of (±)-yezo'otogirin C was established via a bioinspired oxidative cascade cyclization strategy using Mn(II)/Mn(III) and O2, followed by reduction of the peroxy-bridged intermediate using thiourea in refluxi...

Bioinspired Total Synthesis of Bussealin E.

The first total synthesis of bussealin E, a natural product with a unique cycloheptadibenzofuran scaffold, is reported. A strategy inspired by a proposed biosynthesis was employed whereby a diphenylpropane derivative underwent an oxidative phenolic coupling to forge the tetracyclic ring system. The synthesis of the diphenylpropane featured a key sp2-sp3 Hiyama coupling between a vinyldisiloxane...